|
KMID : 0043319950180010001
|
|
Archives of Pharmacal Research
1995 Volume.18 No. 1 p.1 ~ p.7
|
|
|
General Pharmacology of IY-80843, a new H2-Receptor Antagonist;Effects on the Central Nervous and Cardiovascular Systems
|
|
Kim Eun-Joo
Shin Hwa-Sup
Ryu Shi-Yong
Lee Byung-Ho
Cho Soon-Hyun
|
|
|
Abstract
|
|
|
|
IY-80843, N[2-(2-methoxyphenyl)ethyl]-N’-[4-(lmidazole-4-yl)phenyl] formamidine, is a new potent anagonist. The potential secondary pharmacologic effects of this agent, on the central nervous and cardiovascular systems were studied. IY-80843 caused ptosis, suppression of locomotion, hypotehrmia, prolongation of sleeping time and hypotensive effects in mice, rats and dogs. These results suggest that IY-80843 affects the funcition of the central nervous and cardiovascular systems in a dose-dependent manner.
|
|
|
KEYWORD
|
|
|
IY-80843, Pharmacology, Central nervous sytstem, Cardiovascular system
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|